In Vitro & In Vivo Tests:
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Bioassays and Models The following table lists all the operational assays, models and tests currently available at Trinity. We are able to develop new models or adapt existing ones if you need a special model. Condition | Invitro | Invivo | | 1. Rat aortic ring | 1. Rat mesenteric window | 2. Human umbilical venule/ arteriole | | 3. Macula/retina | | 4. Sclera | | 5. Choroid | | 6. HUVEC | | 7. BAEC | | | 1. Primary adipocytes | 1. Zucker obese rat | 2. Primary hepatocytes | 2. High fat diet (mouse & rat) | 3. Hormones, modulators | 3. Metabolic syndrome rodent models | | 1. Neutrophils | | 2. Primary monocytes | 3. Primary macrophages | | 1. Culture of pancreatic islets | 1. ZDF Rats | 2. Glucose uptake by skeletal muscle | 2. Streptozotocin rats | 3. Glucose uptake by adipocytes | | 4. Glucose uptake by hepatocytes | | | 1. Melanoma (mouse & human) | 1. Melanoma (mouse & human) | 2. Colon | 2. Colon | 3. Brain | 3. Brain | 4. Lung | 4. Lung | 5. Breast | 5. Breast | 6. Prostate | 6. Prostate | 7. Phaechromocytoma | 7. Phaechromocytoma | 8. Basal cell carcinoma | 8. Basal cell carcinoma | 9. Squamous cell carcinoma | 9. Squamous cell carcinoma 10 Chemical induced colon (rat) | | 1. Thrombolysis | 1. Platelet function | 2. Clotting | | | 1. Chondrocyte cultures | 1. Acute joint inflammation | 2. Synoviocyte cultures | 2. Rheumatoid arthritis | | 3. Osteoarthritis | | 1. Hepatocyte cultures | 1. Liver function | 2. Liver metabolism | 2. Fibrosis & Sclerosis | | 3, Liver metabolism | | 4. Toxicology | | Hypertension | 1. ANG Recptors | 1. SHR Rats | 2. ACE Inhibition | |
Condition | Invitro | Invivo | | 1. Collagen genetic variants | 1. Fibrosis models | 2. Collagen synthesis | 2. Extracellular matrix | 3. Collagen degradation | 3. Collagen composition and metabolism | 4. Elastin metabolism | 4. Elastin composition and metabolism | 5. Elastin degradation | 5. Glycosaminoglycan, proteoglycan composition and metabolism | 6. Basement membrane | | 7. Glycosaminoglycans | | 8. Proteoglycans | | 9. Fibroblast cultures | | 10. Smooth muscle cell cultures | | | 1. Total anti-oxidative capacity | 1. Total anti-oxidative capacity (serum) | 2. Measurement of reactive oxygen | 2. Measurement of reactive oxygen | 3. Assay of oxidative metabolism | 3. Assay of oxidative metabolism | 4. Lipid oxidation | 4. Lipid oxidation | 5. Protein oxidation | 5. Protein oxidation | 6. Oxidation enzymes | 6. Oxidation enzymes | 7. Anti-oxidative effects | | Amino Acid Analysis | 1. Protein analysis | | 2. Collagen and elastin analyses | 3. Serum amino acids | Dermatology | 1. Skin fibroblast cultures | | 2. Skin keratinocyte cultures | 3. Metabolism of skin cells | 4. Stressed skin cells (eg UV radiation , oxidation) | 5. Mast cells | 6. Skin transport | 7. Skin absorption | 8. Metabolism of skin tissue | 9. Stressed skin tissue (eg UV radiation , oxidation) | 10. Skin inflammation | 11. Skin allergic reaction | 12. Atopic dermatitis 13. Skin tanning 14. Skin whitening | | 1. Mast cell cultures | | 2. Histamine production | Immune reactivity | 1. T cell proliferation | 1. Spleen immune cells | 2. T cell metabolism | 2. Peyers patches cells | 3. NK cells | 3. Immunoglobulins | 4. T reg cells | | 5. B cells | | | 1. Macula angiogenesis | | 2. Retinal angiogenesis | 3. Choroid angiogenesis | 4. Sclera angiogenesis 5. Cataracts |
Condition | Invitro | Invivo | | 1. Gut transport | 1. Inflammatory bowel disease | 2. Smooth muscle contraction/relaxation | 2. Bioavailability | | | 1. Serum lipids | 2. High-Cholesterol diets | 3. Metabolic Syndrome models | Alzheimers disease | 1, Apoptosis | | 2. Amyloid plaques | 3. PC-12 cells | 4. Foetal hippocampus cultures | Wound healing | 1. Fibroblast wounds | 1. Excisional wounds (Healthy rats) | 2. Angiogenesis | 2. Excisional wounds (Diabetic rats) | | 3. Delayed wound healing | | 4. Flaps | | 5. 'Scaffolds' for wounds | Foetal development | | 1. Mating | 2. Conception | 3. Pregnancy and gestation | 4. Delivery | 5. Anatomy | Microbial Assays | 1. Bacterial cultures | | 2. Viral cultures | 3. Fungal cultures | 4. Anti-infectives 5. Antiseptics | Safety & Toxicity | 1. Cytotoxicity | 1. Sub-chronic | | 2. Chronic | | 3. Acute | | 4. Specific systems (eg neuro, renal etc) | | 5. Reproductive | | | |
Contacts Paul Davis, Geoff Todd +64 (0)4 9749286 or +64 (0)9 2803230 www.trinitybioactives.com
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