Trinity Bioactives Ltd. began in 1994 as the Bioactivity Investigation Group (BIG) under the leadership of Dr. Paul Davis at the Wellington campus of the University of Otago Medical School. BIG developed an extensive array of assays and models and, more importantly, experience in using these to help clients with their product development.

Trinity Bioactives purchased BIG from the university in August 2008 and since 2012 has been located on the Callaghan Innovation campus in Gracefield.